Enlist™ Weed Control System FAQs

Two men in Enlist soybean field

Find straightforward answers on the Enlist™ weed control system

Will the Enlist™ system give me the weed control results I’m looking for?

The Enlist weed control system is here for the long haul, and here’s why: It’s based in science and backed by stewardship. This unrivaled system starts with Enlist herbicide-tolerant traits that enable the use of our powerful Enlist herbicides. And to make sure you get the most from the system, the Enlist Ahead management resource provides tools, training and rewards.

The Enlist weed control system allows you to employ Enlist herbicides as the cornerstone of a herbicide program program program approach to overcome your toughest weed challenges — including Palmer amaranth, waterhemp and giant ragweed. Enlist Duo® herbicide with Colex-D® technology combines the proven performance of 2,4-D choline and glyphosate in a convenient, proprietary blend. Enlist One® herbicide is a straight-goods 2,4-D choline with Colex-D technology that provides additional tank-mix flexibility with products such as Liberty® herbicide, residual herbicides, fungicides and insecticides listed on EnlistTankMix.com.








What tolerances are in Enlist E3® soybeans, Enlist® cotton & Enlist™ corn?

Enlist traits enable control against the toughest weeds in soybeans, cotton and corn. With multiple herbicide tolerances, you have more weed control options in one complete, easy-to-use system.

You get tolerance to 2,4-D choline and glyphosate with all Enlist crops, as well as additional glufosinate tolerance in Enlist® cotton and Enlist® cotton and Enlist E3® soybeans and additional FOP herbicide tolerance in Enlist corn. For broad-spectrum grass and broadleaf control, glyphosate with Enlist One® herbicide. For acres with Palmer amaranth, waterhemp and kochia, Liberty® herbicide is the preferred glufosinate for the Enlist weed control system to give you better control and flexibility with weed management.

What are the advantages of the Enlist™ system vs. in-crop dicamba system?

Application window: The 2,4-D choline tolerance in Enlist crops provides a wide application window for Enlist herbicides! Unlike dicamba, there are no calendar cutoff dates for applications of Enlist herbicides. Remember to always read and follow label requirements. Here are the application windows for Enlist herbicides:








  • Enlist E3® soybeans: Through R1 growth stage.
  • Enlist® cotton: Up to first white bloom.
  • Enlist corn: No larger than V8 growth stage or 30 inches tall, whichever happens first.








Near-zero volatility: The 2,4-D choline with Colex-D® technology in Enlist herbicides also results in reduced physical drift potential, near-zero volatility and better handling characteristics. Compared with the in-crop dicamba products (no qualified glufosinate tank-mix partners, only K-salt glyphosate qualified partners), tank-mixing glyphosate and glufosinate with Enlist One® herbicide does not affect the near-zero volatility properties of 2,4-D choline. Watch this YouTube video to learn more about the volatility profile for Enlist herbicides versus dicamba.




Buffer zones: The dicamba system requires a 240-foot downwind buffer. Additional buffers are required in endangered species areas, as designated by EPA's Bulletins Live website: a 57-foot omnidirectional buffer, as well as a 310-foot downwind buffer are required. The Enlist system requires a 30-foot downwind buffer (in the direction in which the wind is blowing) from any area except:




  • Roads (paved or gravel surfaces)
  • Planted agricultural fields (except those crops mentioned in the "Susceptible Plants” section)
  • Agricultural fields that have been prepared for planting
  • Areas covered by the footprint of a building, shade house, greenhouse, silo, feed crib or other man-made structure with walls and/or roof




View the Application Guide


Where can I find tank-mix information for Enlist™ herbicides?

Check out the herbicide partner page for tank-mix options for Enlist® herbicides to fit your weed pressures. You can also find a full list of more than 1,600 qualified tank-mix products with Enlist One® herbicide — herbicides, fungicides, insecticides and adjuvants — at EnlistTankMix.com. _rte_href="https://www.enlist.com/en/herbicides/approved-tank-mix.html">EnlistTankMix.com. Learn how to successfully spray Enlist herbicides by following the proper tank-mix order.

The Enlist weed control system allows you to employ Enlist herbicides as the cornerstone of a herbicide program approach to overcome your toughest weed challenges with tank-mix flexibility. The flexibility of Enlist One herbicide allows you to customize tank-mix options as well as the ratio of herbicides based on the weed pressure on the acre being sprayed.

On acres with high pressure of glyphosate-resistant broadleaf weeds, like waterhemp, Palmer amaranth and kochia, we recommend a tank mix of Enlist One herbicide + Liberty® herbicide. This tank mix is the most effective and powerful postemergence treatment to control these weeds in fields of Enlist E3® soybeans.

If you have heavy grass pressure, use a tank mix of Enlist One and glyphosate herbicides applied postemergence through R1 growth stage.

Which nozzles and pressure ranges should I use with Enlist™ herbicides?

Make your herbicide applications more successful by following the product label and selecting the right qualified nozzles to optimize coverage and manage driftable fines. The right nozzles can maximize product performance by managing the interaction between application volume, nozzle flow rate, nozzle type, operating pressure, travel speed, nozzle spacing and droplet size category.

Key items to remember:

  • Use a labeled nozzle that provides the best possible coverage while appropriately managing spray droplets.
  • Use no less than 10 gallons of water carrier volume; 10 to 15 gallons recommended for Enlist® herbicides.
  • Take advantage of the flexibility provided by the listed nozzles and pressure ranges to select one that allows you to balance crop coverage and droplet size.


Only use nozzle and pressure combinations specifically listed on the labels for Enlist Duo® and Enlist One® herbicides. You can find a list of qualified nozzles for Enlist One herbicide here and Enlist Duo herbicide here.

What is the application window for Enlist™ herbicides on Enlist crops?

Enlist® herbicides can be applied on Enlist traited crops from burndown through postemergence. Below is the application window listed by crop. The labeled application window for Enlist herbicides is based on crop growth stage, with no calendar cutoff dates. The wide application window for an Enlist herbicide offers opportunities for tank mixes with other qualified products, such as herbicides, insecticides, fungicides, micronutrients and adjuvants. Remember to always read and follow label requirements.

Application Window:

  • Enlist E3® soybeans: Through R1 growth stage.
  • Enlist® cotton: Up to first white bloom.
  • Enlist corn: No larger than V8 growth stage or 30 inches tall, whichever happens first.


Will Enlist™ herbicides make Enlist E3® soybeans or Enlist® cotton droop?

You may see temporary crop response with Enlist E3® soybeans and Enlist® cotton within a few hours of applying Enlist herbicides. This cosmetic response does not impact yield. This “droop” or “sleepy” effect on the crop occurs while the plant is working to metabolize 2,4-D choline. It is more likely to occur in conditions where the plant is stressed, including hot daytime temperatures. The plants metabolize the 2,4-D choline and return to normal, typically within 24 to 48 hours. For more information, watch this YouTube video on droop.

Which adjuvants are required with Enlist™ herbicides?

The Enlist herbicide labels do not require use of any adjuvants, but they may help optimize your tank mix. You can select from many qualified ammonium sulfate (AMS) products and defoamers, as well as many other adjuvant options, listed on EnlistTankMix.com. . Follow the proper tank-mix sequence when using compatibility agents, like adjuvants. For more tank-mix tips, watch this YouTube video.

How many applications of Enlist™ herbicides can I make in one season?

Up to three applications of Enlist herbicide are labeled for use on Enlist crops, and you can find details on the Enlist herbicide labels. You’ll have the greatest success in weed management if you use an Enlist herbicide as part of a program approach for weed control in Enlist crops. This helps manage herbicide resistance, improves weed control and reduces weed competition during key stages of crop growth. Enlist herbicides can be used in burndown, preemergence and postemergence on crops with the Enlist trait. 




Key items to remember:




  • Up to three applications may be made per season at the high rate:
    • One application in burndown or preemergence
    • Up to two applications postemergence, at least 12 days apart
  • Always use a true broad-spectrum soil residual herbicide (not Group 4 or Group 9) in your weed management plan.
  • Consider using a layered residual, such as EverpreX® herbicide, in your post passes for longer-lasting weed control.




Do Enlist™ crops have plant-back limits after an Enlist herbicide burndown?

Enlist herbicides can be used as a burndown on acres of Enlist crops. A burndown application of Enlist One® or Enlist Duo® herbicide means no plant-back restriction to Enlist E3® soybeans and Enlist® cotton, which means you can plant the same day. 

Where can I buy seed with the Enlist™ trait and Enlist herbicides?

Enlist E3® soybeans are available in a wide range of maturities to fit most soybean-growing geographies. All Corteva seed brands sell E3 soybeans: Pioneer®Brevant Seeds,  Seed Consultants®NuTech Seed®AgVenture® and Dairyland Seed®. Additionally, more than 120 seed organizations have licensed Enlist E3 soybeans. You can find a full listing on Enlist.com > Buy Enlist E3 soybeans. Each seed organization manages its line-up of Enlist E3 soybeans, with varieties that have agronomic packages and maturity ranges to fit their customers. Talk with your local seed dealer to find Enlist E3 soybeans for your area and relative maturity.  

The Enlist® cotton trait is available exclusively from PhytoGen® cottonseed. The product lineup continues to expand as farmers increase the number of Enlist cotton acres they plant each year.

As for Enlist corn, Corteva Agriscience seed brands — Brevant Seeds, Dairyland Seed and NuTech Seed — are offering hybrids with the Enlist trait technology in their corn portfolios.

To purchase Enlist herbicides, you can find your local Corteva Agriscience representative or talk with your local crop protection retailer.

Where can I learn more about how the Enlist™ weed control system works?

Enlist Ahead is a management resource that offers tools, training and rewards. Visit the Enlist Ahead page to find the Product Use Guide, Application Guide and a variety of fact sheets. For even more information, you can visit the Enlist Ahead training page to get best-in-class training on the Enlist system. From applicator training sessions to online modules focused on Enlist training, we have a resource for you.

Are Enlist® herbicides safe?

Enlist® herbicides have undergone rigorous regulatory review and testing to ensure they are safe. In fact, 2,4-D, a key active ingredient in Enlist One® and Enlist Duo®, is one of the world’s most studied active ingredients.

More than 4,000 rigorous, peer-reviewed studies have been published confirming that when used as directed, Enlist products are safe for human and animal health, and for the environment. What’s more, they are specially formulated to be easy to use and apply – and to stay where they are sprayed.

Enlist® herbicides are formulated using 2,4-D with Colex® D technology to reduce the potential for drifting of the products beyond the treated area. This innovative formulation also helps to prevent the product from volatilizing and ending up on nearby crops, fields or backyards. 

Enlist® herbicides are stable, with near zero volatility, meaning they do not easily volatilize, or turn into an airborne gas, when the temperature changes after application. They stay where they’re sprayed, do their job, and break down. They do not persist in the environment.


We work with our farmers to help ensure that they have the resources to apply Enlist® herbicides to crops safely and effectively. Enlist™ Ahead is a management resource that offers tools, training. Visit the Enlist Ahead page to find the Product Use Guide, Application Guide and a variety of fact sheets.

For best-in-class training on the Enlist system, visit the Enlist Ahead training page. From applicator training sessions to online modules focused on Enlist training, we have a resource for you.

Pioneer® brand products are provided subject to the terms and conditions of purchase which are part of the labeling and purchase documents.  ® Brevant, Colex-D, Corteva Agriscience, Dairyland Seed, DuPont, Enlist, Enlist Duo, Enlist E3, Enlist One, EverpreX, NuTech, PhytoGen and Pioneer are trademarks of Corteva Agriscience and its affiliated companies. ® Liberty is a registered trademark of BASF.  The transgenic soybean event in Enlist E3 soybeans is jointly developed and owned by DowAgroSciences LLC and MS Technologies, LLC. Enlist Duo® and Enlist One® herbicides are not registered for sale or use in all states or counties. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your area. Enlist Duo and Enlist One herbicides are the only 2,4-D products authorized for use with Enlist crops. Consult Enlist herbicide labels for weed species controlled. EverpreX® is not registered for sale or use in all states. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your state. Always read and follow label directions.